Scopula erubescens is a moth of the Geometridae family. It is found in India (Khasia Hills). William Theophilus Dortch (August 23, 1824 – November 21, 1889) was a prominent North Carolina and Confederate States of America politician and lawyer. Dortch was born August 23, 1824 to William Dortch and his wife, Drusilla at his father's plantation, situated in Nash County.

Development of the COMFIDENT technology

In 2017, our team at Karolinska Institutet developed COMplexome FIngerprint DEconvolutioN Technology (COMFIDENT), an innovative workflow combining statistical modeling with experimental protein synthesis techniques for analyzing protein complexes. This method requires a comprehensive high-throughput proteomics assay for each specific protein complex. Following the completion of these experiments, the resultant Complex Fingerprint Matrix (CFM) enables the evaluation of high-dimensional protein complexes using advanced proteomics data.

For the past five years, our team has meticulously conducted protein synthesis experiments to generate a high-quality CFM for approximately 2,000 verified protein complexes. In our initial application of this technology, we assessed 1,600 complexes in more than 30,000 individuals. The findings were remarkable, uncovering previously unknown biomarkers for complex diseases that were undetectable using existing proteomic assays.

For detailed information, see our White Paper for the workflow of COMFIDENT and our preprint publication for the analysis results.

Advancing the proteomics field

The proteomics market is currently experiencing significant growth, indicating a promising potential for technologies like COMFIDENT. As of 2024, the global proteomics market is projected to reach around USD 27.60 billion and is expected to grow at a compound annual growth rate (CAGR) of 14.6%, reaching approximately USD 72.9 billion by 2028. This growth is driven by factors such as the rising demand for personalized medicine, increasing research and development expenditure, and technological advancements in the field.

In terms of market segmentation, the reagents and consumables segment holds a substantial share, accounting for more than 70.30% of the global revenue in 2021. This segment is also anticipated to exhibit the fastest growth rate during the projected period. This growth can be attributed to the extensive use of reagents and consumables in various biological research settings, combined with technological developments in instruments like 2-D electrophoresis protein analyzers, which improve research efficiency.

The clinical diagnostics segment dominates the proteomics industry, with a significant share of more than 51.65% in 2021. This dominance is due to the high adoption of protein analysis in clinical research for identifying disease biomarkers and risk factors, which opens new opportunities for prevention and early intervention of diseases.

Given these market dynamics, the COMFIDENT technology, with its focus on high-dimensional protein complex analysis, could be well-positioned to capitalize on the growing proteomics market. Its potential to uncover novel biomarkers for complex diseases aligns with the current market trend towards personalized medicine and clinical diagnostics. Furthermore, the demand for advanced and efficient diagnostic tools and drug discovery platforms is on the rise, which could further justify the potential profitability and market size for COMFIDENT.

The simple Image Post

The system utilised prefabricated light gauge steel frames which could be built economically up to a maximum of 4 storeys. The frames were finished in a variety of claddings and their modular nature could be employed to produce architecturally satisfying buildings. Initially developed solely for schools, the system was also used to provide offices and housing. Important examples include many of the Hertfordshire schools, some of which have since been listed.

Another notable use of CLASP is the University of York, designed by architect Andrew Derbyshire. A later development was known as SCOLA (Second Consortium of Local Authorities) and MACE (Metropolitan Architectural Consortium for Education). The cynics' definition of the CLASP acronym, circulating in the 1970s, was "collection of loosely assembled steel parts". Langwith College, University of York. A notable use of the CLASP system. Vanbrugh College, University of York.

The simple Gallery Post

The system utilised prefabricated light gauge steel frames which could be built economically up to a maximum of 4 storeys. The frames were finished in a variety of claddings and their modular nature could be employed to produce architecturally satisfying buildings. Initially developed solely for schools, the system was also used to provide offices and housing. Important examples include many of the Hertfordshire schools, some of which have since been listed.

Another notable use of CLASP is the University of York, designed by architect Andrew Derbyshire. A later development was known as SCOLA (Second Consortium of Local Authorities) and MACE (Metropolitan Architectural Consortium for Education). The cynics' definition of the CLASP acronym, circulating in the 1970s, was "collection of loosely assembled steel parts". Langwith College, University of York. A notable use of the CLASP system. Vanbrugh College, University of York.